Change of Th17 lymphocytes and Treg/Th17 in Typical and Atypical Optic Neuritis (.pdf)

Typical and atypical optic neuritis (ON) are two types of autoimmune inflammatory diseases of the optic nerve that causes acute vision loss, and which are difficult to distinguish in their early stages. The disturbance in the balance of Th17 and Treg lymphocytes is thought to play an essential role in these autoimmune inflammatory diseases. To detect the clinical relevance of Th17 and Treg in peripheral blood and the ratio of Treg/Th17 in patients with typical and atypical ON. To explore potential methods with which to distinguish typical and atypical ON based on their distinct pathogenesis.