The Photopic Negative Response as an Objective Measurement of Visual Function in Patients with Leber's Hereditary Optic Neuropathy (.pdf)

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Identifier 20160301_nanos_posters_141
Title The Photopic Negative Response as an Objective Measurement of Visual Function in Patients with Leber's Hereditary Optic Neuropathy (.pdf)
Creator Rustum Karanjia, Stuart Coupland, Shellee Rockwell, Alfredo A. Sadun
Subject Optic Neuropahty, Visual Fields, Diagnostic Tests
Description The photopic negative response (PhNR) is a slow negative component of a flash photopic full field ERG which has been shown to be specific for retinal ganglion cell (RGC) activity. Direct evaluation of RGC function is important in patients with Leber's Hereditary Optic Neuropathy (LHON) in which functional improvement with Idebenone and EPI-743 can take years to be clinically measurable, presumably due to the time required for CNS remodeling. Thus there is a need for objective non-invasive clinical metric in patients with LHON which does not rely on fixation and has the promise of directly measuring RGC activity. The purpose of this study was to evaluate the use of PhNR as a potential clinical metric for patients with LHON.
Date 2016-03-01
Language eng
Format application/pdf
Format Creation application.pdf
Type Text
Source 2016 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS Annual Meeting 2016: Poster Presentations
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Rights Management Copyright 2016. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6bk4k6q
Context URL The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/
Contributor Primary Rustum Karanjia
Contributor Secondary Stuart Coupland, Shellee Rockwell, Alfredo A. Sadun
Setname ehsl_novel_nam
ID 185158
Reference URL https://collections.lib.utah.edu/ark:/87278/s6bk4k6q
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