Neuro-Ophthalmologic Manifestations of Cholangiocarcinoma: A Case Series (.pdf)

Cholangiocarcinoma is a rare liver malignancy originating in the biliary epithelium. Patients may present with signs and symptoms of biliary obstruction, or nonspecific complaints such as malaise, weight loss, and night sweats. It is uncommon for this malignancy to spread distally and our review of the literature identified only 16 cases of brain metastasis from cholangiocarcinoma none of which presented neuro-ophthalmologic manifestations. Metastasis to the brain and orbit can result in neuro-ophthalmologic deficits such as diplopia, proptosis, and decreased vision. We present the first and largest series of the neuro-ophthalmologic manifestations of cholangiocarcinoma.