Long Distance Homonymous Hemi-Macular Retrograde Degeneration of the Visual Pathway

Trans-synaptic degeneration of the visual pathway following ablation of the striate cortex is well established in nonhuman primates and involves parvocellular retino-geniculate connections. In humans, trans-synaptic degeneration is more controversial but has been described recently. In this study, we used optical coherence tomography (OCT) to examine the severity and timing of retrograde degeneration in human anterior (optic tract, lateral geniculate nucleus) and posterior (occipital) visual pathway lesions.