How does Exogenous ROS Effect LHON Conversion

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Identifier 20150222_nanos_posters_069
Title How does Exogenous ROS Effect LHON Conversion
Creator Jeffrey Tran, Youning Zhang, Rustum Karanjia, Chiara La Morgia, Solange R. Salomao, Adriana Berezovsky, Filipe Chicani, Milton Moraes, Milton M Filho, Rubens Belford Jr., Alfredo A. Sadun, Valerio Carelli
Subject Genetic Disease; Optic Neuropathy
Description "Mitochondrial DNA mutations associated with Leber's hereditary optic neuropathy (LHON) are associated with endogenous reactive oxygen species (ROS) production. Research has demonstrated that exogenous ROS generators, like smoking, are associated with an earlier age of conversion from carrier to affected state. However, the exact role of exogenous ROS in LHON is ill defined. To understand the role of exogenous ROS in LHON, we hypothesize dividing LHON into two subtypes. I: conversion is predominantly genetically determined and largely independent of exogenous ROS and II: the genetic component is necessary but insufficient for conversion and exogenous ROS exposure is required."
Relation is Part of NANOS 2015: Poster Presentations
Contributor Primary Jeffrey Tran
Contributor Secondary Youning Zhang, Rustum Karanjia, Chiara La Morgia, Solange R. Salomao, Adriana Berezovsky, Filipe Chicani, Milton Moraes, Milton M Filho, Rubens Belford Jr., Alfredo A. Sadun, Valerio Carelli
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2015-02-22
Type Text
Format application/pdf
Format Creation application/pdf
Source 2015 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
ARK ark:/87278/s69w3nbr
Setname ehsl_novel_nam
Date Created 2015-03-26
Date Modified 2016-08-01
ID 184508
Reference URL https://collections.lib.utah.edu/ark:/87278/s69w3nbr
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