Low-Contrast Letter Acuity Loss Over Time in Multiple Sclerosis Correlates with Reductions in Retinal Nerve Fiber Layer Thickness and Macular Volume by OCT

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Identifier 20070213_nanos_sciplatform_01.pdf
Title Low-Contrast Letter Acuity Loss Over Time in Multiple Sclerosis Correlates with Reductions in Retinal Nerve Fiber Layer Thickness and Macular Volume by OCT
Creator Burkholder, Bryn; Winslow, Heather; Nano-Schiavi, M. L.; Pulicken, Mathew; Calabresi, Peter; Galetta, Steven L; Frohman, Elliot; Balcer, Laura J
Subject low-contrast letter acuity; optical coherence tomography (OCT); multiple sclerosis (MS); visual function; axonal loss
Description Low-contrast letter acuity testing is being used with increasing frequency as an MS trial outcome. This measure demonstrated treatment effects in recent phase 3 trials of natalizumab, capturing sustained, clinically-significant visual loss. Optical coherence tomography (OCT) parameters of retinal nerve fiber layer (RNFL) thickness and macular volume are reduced in eyes of MS patients, and also demonstrate promise as MS trial endpoints. We sought to examine correlations between low-contrast letter acuity losses over time with changes in RNFL thickness and macular volume in an MS cohort.
Relation is Part of NANOS 2007: Scientific Platform Presentations (Session II)
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Type Text
Format application/pdf
Format Creation application/pdf
Source 2007 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2010. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Language eng
ARK ark:/87278/s6t75pvr
Setname ehsl_novel_nam
Date Created 2011-07-06
Date Modified 2021-05-06
ID 180936
Reference URL https://collections.lib.utah.edu/ark:/87278/s6t75pvr
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