Ain't No Sunshine When You Are Gone!

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Identifier walsh_2013_s1_c2-2
Title Ain't No Sunshine When You Are Gone!
Creator Shah, Veeral S; Sternau, Linda L; Felicella, Michelle; Dubovy, Sanders; Alabiad, Chris; Norman J. Schatz, M.D., Bascom Palmer Eye Institute; Lam, Byron L
Subject Adulthood Malignant Glioma; Optic Neuritis; Anaplastic astrocytoma; Temozolomide; Central Vein/Artery occlusion
Presenting Symptom An 18 year-old Latin American female presented with progressive visual loss OD over 6 weeks.
History An 18 year-old Latin American female presented with progressive visual loss OD over 6 weeks. She initially had blurry vision and photophobia OD with a central scotoma OD on HVF testing. At that time, examination revealed a right swollen optic nerve with retinal hemorrhages. She was otherwise healthy, and denied any eye pain, neurological deficits, trauma medications, tobacco, alcohol, or drug use.
Clinical A fat suppressed orbital MRI scan showed evidence of optic nerve enhancement OD.
Neuroimaging MRI
Pathology Intracanalicular right optic nerve specimen showed dense fibrovascular tissue with macrophage infiltrates. Intracranial portion of the right optic nerve specimen revealed large pleomorphic and hyperchromatic atypical cells infiltrating the nerve. Sectioned tissue underwent immunostaining for GFAP, Ki67, Olig 2, and IDH1. These atypical cells were strongly GFAP positive, but were negative for Olig and IDH1. The Ki67 index of the posterior margin of the tissue was 4-5%.
Disease/Diagnosis Malignant Glioma optic nerve pathway (a pediatric case of Malignant Glioma of Adulthood)
Treatment This patient was managed aggressively with surgical resection of the pre-chiasmal tumor, and treated post-operatively with Temozolomide and stereotactic radiotherapy treatment.
Relation is Part of Case presented at the NANOS 2013 Walsh Session, February 10
Contributor Primary Bruce, Beau B
Contributor Secondary Phillips, Paul H
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2013-02-10
Type Image/MovingImage
Format video/mp4
Rights Management Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
Holding Institution North American Neuro-Ophthalmology Association (NANOS), Copyright 2013. For further information regarding the rights to this collection, please visit http://library.med.utah.edu/NOVEL
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Language eng
ARK ark:/87278/s6jh6hr0
Setname ehsl_novel_fbw
Date Created 2015-02-21
Date Modified 2017-02-22
ID 179232
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jh6hr0
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