Ain't No Sunshine When You Are Gone!

Update item information
Identifier walsh_2013_s1_c2
Title Ain't No Sunshine When You Are Gone!
Creator Veeral S. Shah, Linda L. Sternau, Michelle Felicella, Sanders Dubovy, Chris Alabiad, Norman J. Schatz, MD, Bascom Palmer Eye Institute; Byron L. Lam
Subject Adulthood Malignant Glioma; Optic Neuritis; Anaplastic astrocytoma; Temozolomide; Central Vein/Artery occlusion
History An 18 year-old Latin American female presented with progressive visual loss OD over 6 weeks. She initially had blurry vision and photophobia OD with a central scotoma OD on HVF testing. At that time, examination revealed a right swollen optic nerve with retinal hemorrhages. She was otherwise healthy, and denied any eye pain, neurological deficits, trauma medications, tobacco, alcohol, or drug use.
Pathology Intracanalicular right optic nerve specimen showed dense fibrovascular tissue with macrophage infiltrates. Intracranial portion of the right optic nerve specimen revealed large pleomorphic and hyperchromatic atypical cells infiltrating the nerve. Sectioned tissue underwent immunostaining for GFAP, Ki67, Olig 2, and IDH1. These atypical cells were strongly GFAP positive, but were negative for Olig and IDH1. The Ki67 index of the posterior margin of the tissue was 4-5%.
Disease/Diagnosis Malignant Glioma optic nerve pathway (a pediatric case of Malignant Glioma of Adulthood)
Clinical A fat suppressed orbital MRI scan showed evidence of optic nerve enhancement OD.
Presenting Symptom An 18 year-old Latin American female presented with progressive visual loss OD over 6 weeks.
Neuroimaging MRI
Treatment This patient was managed aggressively with surgical resection of the pre-chiasmal tumor, and treated post-operatively with Temozolomide and stereotactic radiotherapy treatment.
Date 2013-02-10
References Attached
Language eng
Format application/pdf
Type Text
Source 45th Annual Frank Walsh Society Meeting
Relation is Part of Case presented at the NANOS 2013 Walsh Session, February 10
Collection Neuro-ophthalmology Virtual Education Library: NOVEL
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Holding Institution North American Neuro-Ophthalmology Association (NANOS), Copyright 2013. For further information regarding the rights to this collection, please visit
ARK ark:/87278/s6tb44h9
Contributor Primary Bruce, Beau B
Contributor Secondary Phillips, Paul H
Setname ehsl_novel_fbw
ID 179168
Reference URL