Hear No Evil, See No Evil

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Identifier walsh_2009_s4_c2
Title Hear No Evil, See No Evil
Creator Sashank Prasad, MD, Brigham and Women's Hospital
Subject Mitochondrial Encephalomyopathies; MELAS Syndrome; Point Mutation; Hearing Loss, Sensorineural; Scotoma; Pupil Disorders; Optic Neuritis
Presenting Symptom Painless loss of vision OS
History A 62-year old female with painless loss of vision OS. Previous history significant for bilateral sensorineural deafness.
Clinical VA: 20/20 OD, 20/200 OS; Color plates: 8/11 OD, 0/11 OS; RAPD OS
Neuroimaging MRI
Pathology Retinal nerve fiber atrophy; Axonal polyneuropathy; Inherited mitochondrial disorder
Disease/Diagnosis MELAS Syndrome
Treatment N/A
References 1. Dickerson, Holtzman, Grant, Tian. Case records of the Massachusetts General Hospital. Case 36-2005. A 61-year-old woman with seizure, disturbed gait, and altered mental status. N Engl J Med 353, 2271-2280, 2005. 2. Mizrachi, Gomez-Hassan, Blaivas, Trobe. Pitfalls in the diagnosis of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes. J Neuroophthalmol, 26, 38-43, 2006. 3. Apostolova, White, Moore, et al. Deep white matter pathologic features in watershed regions. A novel pattern of central nervous system involvement in MELAS. Arch Neurol 62, 1 1 54-6, 2005. 4. Goto, Nonaka, Horai. A mutation in the tRNA(Leu) (UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature, 348, 651-653, 1990. 5. Scaglia, Northrop. The mitochondrial myopathy encephalopathy, lactic acidosis with stroke-like episodes (MELAS) syndrome: a review of treatment options. CNS Drugs 20, 443-464, 2006.
Relation is Part of Session 4, Case 2, Walsh Session, NANOS 2009
Contributor Primary Prasad, Sashank
Contributor Secondary Callaghan, Brian; Galetta, Steven
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Type Text
Format application/pdf
Source 41st Annual Frank Walsh Society Meeting
Rights Management Copyright 2002. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Language eng
ARK ark:/87278/s63n266x
Setname ehsl_novel_fbw
Date Created 2010-02-12
Date Modified 2021-05-06
ID 178739
Reference URL https://collections.lib.utah.edu/ark:/87278/s63n266x