Chronic Hypoxia Exposure Worsens Depression

Update item information
Identifier chronic-hypoxia
Title Chronic Hypoxia Exposure Worsens Depression
Creator Renshaw, P. M.; Kanekar, S.; Kondo, D. G. U of U Health Key Faculty Collaborators: Yurgelun Todd, D.; Kious, B. M.; Soon, Y.; Shi, X.; Psychiatry; School of Medicine; University of Utah Health
Keyword Mental Health
Image Caption Chronic hypoxia alters brain chemistry to increase vulnerability to depression.
Description University of Utah Health investigator Perry Renshaw, MD, PhD, and colleagues combine epidemiology, animal models, and human neuroimaging to study how impaired brain bioenergetics affect psychiatric disorders. They first reported a link between altitude and suicide in the U.S., a finding since replicated in three other continents. People living at high altitude are exposed to hypobaric hypoxia, and the partial pressure of oxygen in arterial blood is reduced in people at 4,500ft (Salt Lake City, UT) compared to sea level. Both Hypobaric hypoxia and chronic hypoxic conditions such as pulmonary, cardiovascular, and sleep disorders and smoking are linked to depression. Preclinical studies found that hypobaric hypoxia disrupts brain serotonin and bioenergetic systems, with women being particularly vulnerable. Using magnetic resonance imaging, researchers also found that, compared to sea level, humans at 4,500 feet exhibit deficits in creatine, a high energy neurometabolite. The Renshaw Lab subsequently conducted animal and human studies and observed that targeted creatine supplementation improved brain bioenergetics and reduced depressive symptoms. Future goals aim to define the mechanisms by which hypobaric hypoxia promotes depression and suicide risk, and to test new treatment strategies.
Relation is Part of 2018
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2021
Date 2018
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6q58pkp
References 1.) Incidence of major depressive episode correlates with elevation of substate region of residence. DelMastro, K, Hellem T, Kim N, Kondo D, Sung YH, Renshaw PF. J Affect Disord. 2011 Mar;129(1):376. 2.) Altitude, gun ownership, rural areas, and suicide. Kim, N, Mickelson JB, Brenner BE, Haws CA, Yurgelun-Todd DA, Renshaw PF. Am J Psychiatry. 2011 Jan;168(1):49. 3.) Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study. Kondo DG, Sung YH, Hellem TL, Fiedler KK, Shi X, Jeong EK, Renshaw PF. J Affect Disord. 2011 December;135(1):354. 4.) Hypobaric hypoxia induces depression-like behavior in female, Sprague-Dawley rats, but not in males. Kanekar S., Bogdanova OV, Olson PR, Sung YH, D'Anci KE, Renshaw PF. High Alt Med Biol. 2015 Mar;16(1):52. 5.) Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression. Kondo DG, Forrest LN, Shi X, Sung YH, Hellem TL, Huber RS, Renshaw PF. Amino Acids. 2016 August;48(8):1941. 6.) Increased anxiety and anhedonia in female rats following exposure to altitude. Sheth C, Ombach H, Olson P, Renshaw PF, Kanekar S. High Alt Med Biol. 2018 Mar;19(1):81. 7.) Hypobaric hypoxia exposure in rats differentially alters antidepressant efficacy of the selective serotonin reuptake inhibitors fluoxetine, paroxetine, escitalopram and sertraline. Kanekar S., Sheth CS, Ombach HJ, Olson PR, Bogdanova OV, Petersen M, Renshaw CE, Sung YH, D'Anci KE, Renshaw PF. Pharmacol Biochem Behav. 2018 July;170:25.
Press Releases and Media University of Utah Health: "Higher Altitudes Hide Deadly Problem: Increased Risk for Suicide" (2010); "Study Links Thin Air, Higher Altitudes to Depression in Female Rats" (2015); "Common Antidepressents Are Less Effective at High Altitudes, Rodent Study Suggests" (2018); Al Jazeera; Salt Lake Tribune; KUTV; LiveScience; KUER Radio; Deseret News; Vice News; Fox13; KUER; Deseret News
Setname ehsl_50disc
Date Created 2021-06-22
Date Modified 2021-06-25
ID 1703468
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