The Influence of Volume and Anatomic Location of Optic Disc Drusen on the Sensitivity of Autofluorescence

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Title The Influence of Volume and Anatomic Location of Optic Disc Drusen on the Sensitivity of Autofluorescence
Creator Frederik Cornelius Loft, Lasse Malmqvist, Anne-Sofie Wessel Lindberg, Steffen Hamann
Affiliation Department of Ophthalmology (FCL, LM, SH), Rigshospitalet, University of Copenhagen, Denmark; and Department of Applied Mathematics and Computer Science (A-SWL), Technical University of Denmark, Denmark
Abstract Background: Optic disc drusen (ODD) are acellular deposits in the optic nerve head. ODD can be diagnosed using different imaging modalities, including enhanced depth imaging optical coherence tomography (EDI-OCT) and autofluorescence (AF). It is unknown which factors determine the sensitivity of AF. The aim of this study was to investigate the effect of volume and anatomic location of ODD on the sensitivity of AF. Methods: Cross-sectional study. Results: A total of 38 patients (75 eyes) with ODD were included. In 12 of 75 eyes (16%) and in 11 of 38 patients (29%), EDI-OCT detected ODD that were not detected by AF. In 24 distinctly solitary ODD, both increase in ODD volume (P = 0.0388) and a more superficial ODD location (P < 0.0001) increased the possibility of AF detection of ODD, when performing a multivariate analysis. Conclusions: EDI-OCT is superior to AF in the diagnosis of ODD. Volume and anatomic location of ODD have a significant impact on the sensitivity of AF.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2019-03
Type Text
Source Journal of Neuro-Ophthalmology, March 2019, Volume 39, Issue 1
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s66b2t0h
Setname ehsl_novel_jno
Date Created 2020-09-22
Date Modified 2021-05-06
ID 1595795
Reference URL https://collections.lib.utah.edu/ark:/87278/s66b2t0h
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