Review of Cohort Studies: A Companion Article to Malmqvist et al "Progression Over 5 Years of Prelaminar Hyperreflective Lines to Optic Disc Drusen in the Copenhagen Child Cohort 2000 Eye Study"

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Title Review of Cohort Studies: A Companion Article to Malmqvist et al "Progression Over 5 Years of Prelaminar Hyperreflective Lines to Optic Disc Drusen in the Copenhagen Child Cohort 2000 Eye Study"
Creator Victoria L. Tseng, Melinda Y. Chang
Affiliation Department of Ophthalmology (VLT), Stein Eye Institute at the University of California, Los Angeles, California Heed Ophthalmic Fellowship (VLT), San Francisco, California; The Vision Center at Children's Hospital of Los Angeles (MYC), Los Angeles, California; and Department of Ophthalmology (MYC), Roski Eye Center, University of Southern California, Los Angeles, California
Abstract A cohort study is an observational study design that follows a group of individuals (the"cohort") over time to identify risk factors for an outcome of interest (usually a disease) (1). Some individuals in the cohort are exposed to the potential risk factor(s) being studied, whereas others are not exposed. The proportions of subjects in the exposed vs nonexposed groups who develop the outcome of interest are used to estimate the incidence of the outcome based on the exposure status.A cohort study can be closed or open. A closed cohort is one with fixed membership, meaning that no one can be added to the cohort after follow-up begins, and the size of the population at risk decreases as people develop the outcome of interest. An open cohort can take additional members after follow-up has started, and the population at risk can change over the course of the study (2). Because cohort studies are nonrandomized, results may be affected by confounders-that is, factors that influence both the exposure and outcome. Investigators must therefore correct for potential confounders in statistical analyses.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2020-09
Type Text
Source Journal of Neuro-Ophthalmology, September 2020, Volume 40, Issue 3
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s6qz81c2
Setname ehsl_novel_jno
Date Created 2020-09-15
Date Modified 2021-05-06
ID 1592983
Reference URL https://collections.lib.utah.edu/ark:/87278/s6qz81c2
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