Defining Pathways for Bone Destruction and Preservation in Cancer

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Title Defining Pathways for Bone Destruction and Preservation in Cancer
Creator Welm, A.L.
Subject Diffusion of Innovation; Bone and Bones; Osteoporosis; Osteolysis; Osteoclasts; Neoplasms Metastasis; RON protein; Females; Mice, Transgenic; Proto-Oncogene Proteins; Macrophages; Macrophage Activation; Receptor Protein-Tyrosine Kinases; Signal Transduction; Clinical Trials as Topic; Treatment Outcome; Knowledge Discovery
Keyword Cancer
Image Caption A RON Kinase inhibitor reduces bone destruction (CTX marker) and increases bone repair (BSAP marker) in mice. Females (treated), Males (control).
Description Bone destruction occurs during aging and numerous diseases, including osteoporosis and cancer. Many cancer patients, including those with breast-to-bone metastasis, have bone osteolysis that is refractory to state-of-the-art treatments. Macrophage-stimulating protein (MSP) signaling, which is elevated in about 40% of breast cancers, promotes osteolytic bone metastasis by activation of the MSP signaling pathway in tumor cells or in the bone microenvironment. This work shows that MSP signals through its receptor, RON tyrosine kinase, which is expressed on the surface of host cells, to activate osteoclasts directly, by converging on the oncogene SRC. Thus, Welm and colleagues have identified RON tyrosine kinase as a viable target for reducing bone loss in patients who have breast-to-bone metastasis, and provided proof of this principle in mouse models and initial clinical trials.
Relation is Part of 2017
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2017
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6kq3r7d
References 1.) RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis. Andrade K, Fornetti J, Zhao L, Miller SC, Randall RL, Anderson N, Waltz SE, McHale M, Welm AL. Sci Transl Med. 2017 Jan;9(374). pii: eaai9338. https://pubmed.ncbi.nlm.nih.gov/28123075/
Setname ehsl_50disc
ID 1589389
Reference URL https://collections.lib.utah.edu/ark:/87278/s6kq3r7d
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