Mechanism of Cold-induced Thermogenesis

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Title Mechanism of Cold-induced Thermogenesis
Creator Villanueva C.J.
Subject Diffusion of Innovation; Thermogenesis; Carnitine; Adipose Tissue, Brown; Adipose Tissue, White; Hot Temperature; Cold Temperature; Fatty Acids; Liver; Knowledge Discovery
Keyword Diabetes and Metabolism
Image Caption Acylcarnitines (AC) boost body heat to adapt to the cold.
Description Cold-induced thermogenesis is an energy-demanding process that protects warm-blooded animals against reductions in ambient temperature. Villanueva and colleagues demonstrated that in response to cold, the liver switches metabolism to provide acylcarnitines, which are used as fuel by brown fat. Exogenous L-carnitine also rescues the cold sensitivity seen with aging. Thus, this study uncovered an elegant mechanism whereby white adipose tissue provides long-chain fatty acids for hepatic carnitylation and generates plasma acylcarnitines that are used as a fuel source in peripheral tissues.
Relation is Part of 2017
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2017
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6c598w1
References 1.) Global analysis of plasma lipids identifies liver-derived acylcarnitines as a fuel source for brown fat thermogenesis. Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ. Cell Metabolism. 2017 Sep;26(3):509. https://pubmed.ncbi.nlm.nih.gov/28877455/
Press Releases and Media Boosting a Lipid Fuel Makes Mice Less Sensitive to the Cold https://healthcare.utah.edu/publicaffairs/news/2017/09/brown-fat.php; MedicalXpress; Scienceblog
Setname ehsl_50disc
ID 1589383
Reference URL https://collections.lib.utah.edu/ark:/87278/s6c598w1
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