Identifying RNAs from Invading Viruses

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Identifier identifying_RNAs_from_invading_viruses
Title Identifying RNAs from Invading Viruses
Creator Bass, B.L., Shen, P., Iwasa, J.; Biochemistry; School of Medicine; University of Utah Health
Subject Diffusion of Innovation; Viruses; DICER1 protein, human; DEAD-box RNA Helicases; RNA, Double-Stranded; RNA, Viral; Ribonuclease III; eIF-2 Kinase; Gene Expression Regulation;Host-Pathogen Interactions; Gene Expression Regulation; Gene Expression Regulation, Viral; Antiviral Agents; Invertebrates; Knowledge Discovery
Keyword Fundamental Biology
Image Caption Dicer discriminates dsRNA with overhanging termini (self) from viral dsRNA (non-self).
Description Organisms must regulate gene expression and also distinguish their RNA molecules (self) from the RNAs of invading viruses (non-self). Biochemical and structural studies from Bass, Shen, Iwasa, and colleagues revealed how Dicer-2, an RNA processing, and antiviral defense enzyme, distinguishes and differentially processes double-stranded RNA (dsRNA) substrates by sensing the unique chemistry at their termini. The study also revealed that human Dicer evolved with distinct activities from invertebrate Dicers, and this discovery is paving the way for altering the antiviral defense for therapeutic benefits.
Relation is Part of 2018
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2018
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6w43kdh
References 1.) Dicer uses distinct modules for recognizing dsRNA termini. Sinha NK, Iwasa J, Shen PS, Bass BL. Science. 2018 Jan;359(6373):329 https://pubmed.ncbi.nlm.nih.gov/29269422/
Press Releases and Media Detecting & Destroying Intruders https://attheu.utah.edu/facultystaff/detecting-destroying-intruders/; ScienceDaily https://www.sciencedaily.com/releases/2017/12/171221143114.htm; Genetic Engineering and Biotechnology News https://www.genengnews.com/topics/omics/team-shows-how-dicer-protein-detects-and-destroys-viral-invaders/
Setname ehsl_50disc
Date Created 2020-08-13
Date Modified 2021-05-06
ID 1589379
Reference URL https://collections.lib.utah.edu/ark:/87278/s6w43kdh
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