Identifier |
20200310_nanos_sciplatform3_08-slides |
Title |
Ectopic Melanopsin For Visual Restoration: Comparisons with Alternative Optogenetic Tools (Slides) |
Creator |
Michael J. Gilhooley, Moritz Lindner, Steven Hughes, Mark Hankins |
Subject |
Genetic Disease, Pupils Retina |
Description |
Background: Melanopsin is an optogenetic tool - it renders neural cells sensitive to light when exogenously expressed - and is emerging as a prime candidate for clinical optogenetic approaches to visual restoration. A model for this approach lies in the neuroretinal tissue surviving in the inherited retinal degenerations (IRD). However, a diversity of neural light responses naturally exists in the healthy retinae and it remains unclear which optogenetic tool is best suited to fully replicate natural neuroretinal responses. Purpose: To compare melanopsin with leading optogenetic tools exogenously targeted to ON-bipolar cells without the "noise" of intrinsic responses by using retinae devoid of both canonical and pRGC photoreception. |
Date |
2020-03 |
Language |
eng |
Format |
application/pdf |
Source |
2020 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2020: Scientific Platform Session III |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2020. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6vt71z5 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Contributor Primary |
Michael J. Gilhooley, MA, MB, BChir, FRCOphth |
Contributor Secondary |
Moritz Lindner, Steven Hughes, Mark Hankins |
Setname |
ehsl_novel_nam |
ID |
1541354 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6vt71z5 |