Ectopic Melanopsin For Visual Restoration: Comparisons with Alternative Optogenetic Tools (Slides)

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Identifier 20200310_nanos_sciplatform3_08-slides
Title Ectopic Melanopsin For Visual Restoration: Comparisons with Alternative Optogenetic Tools (Slides)
Creator Michael J. Gilhooley, Moritz Lindner, Steven Hughes, Mark Hankins
Subject Genetic Disease, Pupils Retina
Description Background: Melanopsin is an optogenetic tool - it renders neural cells sensitive to light when exogenously expressed - and is emerging as a prime candidate for clinical optogenetic approaches to visual restoration. A model for this approach lies in the neuroretinal tissue surviving in the inherited retinal degenerations (IRD). However, a diversity of neural light responses naturally exists in the healthy retinae and it remains unclear which optogenetic tool is best suited to fully replicate natural neuroretinal responses. Purpose: To compare melanopsin with leading optogenetic tools exogenously targeted to ON-bipolar cells without the "noise" of intrinsic responses by using retinae devoid of both canonical and pRGC photoreception.
Date 2020-03
Language eng
Format application/pdf
Source 2020 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS Annual Meeting 2020: Scientific Platform Session III
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Rights Management Copyright 2020. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6vt71z5
Context URL The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/
Contributor Primary Michael J. Gilhooley, MA, MB, BChir, FRCOphth
Contributor Secondary Moritz Lindner, Steven Hughes, Mark Hankins
Setname ehsl_novel_nam
ID 1541354
Reference URL https://collections.lib.utah.edu/ark:/87278/s6vt71z5
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