A Novel Treatment Approach in a Case of Mosaic Neurofibromatosis Type 2

Neurofibromatosis type 2 (NF2) is a genetic syndrome caused by mutations in the NF2 gene resulting in tumors of the nervous system. While NF2 is commonly thought to follow an autosomal dominant inheritance pattern due to a mutation on chromosome 22 , we present a case of NF2 due to sporadic germline mosaicism. Our goal is to highlight the clinical presentation of a patient with radiological findings consistent with invasive meningioma in the setting of genetic features consistent with mosaic NF2, as well as novel treatment approaches for treatment of a complex high grade and refractory meningioma.