Retinal Arterio-Arterial Collaterals in Susac Syndrome

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Title Retinal Arterio-Arterial Collaterals in Susac Syndrome
Creator Robert A. Egan, MD, Guy Jirawuthiworavong, MD, Norah S. Lincoff, MD,John J. Chen, MD, PhD, Courtney E. Francis, MD, Jacqueline A. Leavitt, MD
Affiliation Department of Neurology and Ophthalmology (RAE), Rockwood Clinic, Spokane, Washington; Southern California Permanente Medical Group (GJ), Los Angeles, California; Department of Neurology and Ophthalmology (NSL), Jacobs School of Medicine, SUNY Buffalo, Buffalo, New York; Departments of Ophthalmology (JJC, JAL) and Neurology (JJC), Mayo Clinic, Rochester, Minnesota; and Department of Ophthalmology (CEF), University of Washington, Seattle, Washington
Abstract Background: The ophthalmic findings of Susac syndrome (SS) consist of visual field defects related to branch retinal artery occlusion (BRAO), and fluorescein angiography (FA) reveals a unique staining pattern. To date, retinal arterial collateral development has been described only in a single patient. Given that the immunopathological process in SS induces retinal ischemia, it is conceivable that abnormal blood vessel development may occur in affected individuals. Methods: This is a retrospective observational study. The medical records including fundus photography and FA of all patients with SS were reviewed, and those with any type of retinal arterial collateral were identified. Results: A total of 11 patients were identified with retinal collaterals. Five were men. Age ranged from 20 to 50 years. Ten patients had arterio-arterial (A-A) collaterals and 1 had arterio-venous (A-V) collaterals, and all had collaterals remote from the optic disc. No collaterals were present at onset of illness and the first developed at 9 months. Conclusions: The literature reveals scant evidence for the association between BRAO and retinal arterial collaterals. Our findings indicate that retinal arterial collaterals in SS are usually A-A and not A-V and may be more common in this disorder than previously believed. Collaterals do not develop early in the disease, and there may be a predilection toward development in men. The chronic inflammatory state of SS may be the stimulus for the development of these arterial collaterals.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2018-12
Type Text
Source Journal of Neuro-Ophthalmology, December 2018, Volume 38, Issue 4
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s6m096cx
Setname ehsl_novel_jno
Date Created 2020-01-08
Date Modified 2020-03-18
ID 1500782
Reference URL
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