Leber Hereditary Optic Neuropathy: from Bedside to Bench to Bedside

This lecture will trace the story of our growing understanding of Leber hereditary optic neuropathy (LHON) from clinical recognition, to the first demonstration of a point mutation in the mitochondrial DNA associated with a human disease, to ground-breaking attempts at gene therapy. Upon completion of this session, participants should be able to: 1) recognize the various clinical phenotypes associated with Leber hereditary optic neuropathy (LHON) 2) apply the appropriate testing to make the diagnosis of LHON and 3) identify the potential treatment options for LHON.