Melanopsin: Targeted Ectopic Expression for Optogenetic Visual Restoration

Update item information
Identifier 20190319_nanos_sciplatform3_05-video
Title Melanopsin: Targeted Ectopic Expression for Optogenetic Visual Restoration
Creator Michael Gilhooley, Moritz Lindner, Steven Hughes, Mark Hankins
Subject Genetic Disease, Pupils Retina, Optic Nerve Trauma and Treatment
Description Expression of melanopsin renders neural cells sensitive to light, and is emerging as a prime candidate for clinical optogenetic approaches to visual restoration. The retinal neural tissue surviving in the inherited retinal degenerations (IRDs) after visual loss presents a model target for such approaches, however it is unclear if targeting specific neuronal populations within this tissue is advantageous over non-specific delivery. A fair comparison between these two methods is made difficult by the persistence of native photosensitive retinal ganglion cell (pRGC) responses in IRD models. Here we describe a novel model lacking all native retinal light responses to allow a more robust comparison of optogenetic targets. The purpose of our study is to test the hypothesis that retinae devoid of both canonical and pRGC photoreception will remove the "noise" of intrinsic responses and allow comparison of targeted expression of melanopsin in ON-bipolar cells with non-specific delivery.
Relation is Part of NANOS 2019: Scientific Platform III
Contributor Primary Michael Gilhooley
Contributor Secondary Moritz Lindner, Steven Hughes, Mark Hankins
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2019-03
Format video/mp4
Source 2019 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Language eng
ARK ark:/87278/s65474xv
Setname ehsl_novel_nam
Date Created 2019-06-10
Date Modified 2019-06-10
ID 1427562
Reference URL https://collections.lib.utah.edu/ark:/87278/s65474xv
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