| Identifier |
20190319_nanos_sciplatform3_04-video |
| Title |
MEK Inhibitor Treatment Promotes Retinal Ganglion Cell Preservation without Preventing Retrobulbar Demyelination in Neurofibromatosis Mice |
| Creator |
Steven Stasheff, Francisco Nadal-Nicolas, Wei Li, Miriam Bornhorst, Yuan Zhu |
| Subject |
Pediatric Neuro-Ophthalmology, Neuro-Ophth & Systyemic Disease (eg. MS, MG, Thyroid), Genetic; Disease, Chemotherapy and Radiation Injury, Higher Visual Functions |
| Description |
To better understand the disparity frequently seen between optic pathway glioma (OPG) characteristics and visual loss among young children with neurofibromatosis type 1 (NF1), we extend our previous findings of anatomic, physiologic, and behavioral abnormalities in an established animal model. We now report differential effects of treatment targeting the MAPK/ERK cellular pathway: 1) preserving retinal ganglion cell (RGC) number, and yet 2) failing to ameliorate demyelination of the retrobulbar optic nerve. |
| Date |
2019-03 |
| Language |
eng |
| Format |
video/mp4 |
| Source |
2019 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS 2019: Scientific Platform III |
| Collection |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s68w7wnw |
| Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
| Contributor Primary |
Steven Stasheff |
| Contributor Secondary |
Francisco Nadal-Nicolas, Wei Li, Miriam Bornhorst, Yuan Zhu |
| Setname |
ehsl_novel_nam |
| ID |
1427561 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s68w7wnw |
