Identifier |
20190319_nanos_sciplatform3_01-video |
Title |
rAAV2/2-ND4 Treatment of Leber Optic Neuropathy: 72-Week Data from the REVERSE Phase III Clinical Trial |
Creator |
Nancy Newman, Mark Moster, Alfredo Sadun, Thomas Klopstock, Catherine Vignal, Valerio Carelli, Patrick Yu-Wai-Man, Jose Sahel, Barrett Katz |
Subject |
Genetic Disease, Optic europathy |
Description |
LHON is a mitochondrially inherited disease that causes bilateral central vision loss. A point mutation in the mitochondrial ND4gene at nucleotide position 11778 accounts for 75% of LHON cases. rAAV2/2-ND4is a gene therapy enabling allotopic expression and delivery of the wildtype ND4 protein to mitochondria within retinal ganglion cells. The clinical efficacy of rAAV2/2-ND4 (GS010) is currently being assessed in several Phase 3 trials of ND4‑LHON subjects. |
Date |
2019-03 |
Language |
eng |
Format |
video/mp4 |
Source |
2019 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2019: Scientific Platform III |
Collection |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6p31fgs |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Contributor Primary |
Nancy Newman |
Contributor Secondary |
Mark Moster, Alfredo Sadun, Thomas Klopstock, Catherine Vignal, Valerio Carelli, Patrick Yu-Wai-Man, Jose Sahel, Barrett Katz |
Setname |
ehsl_novel_nam |
ID |
1427558 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6p31fgs |