| Publication Type |
dissertation |
| School or College |
School of Medicine |
| Department |
Family & Preventive Medicine |
| Author |
Adams, Ted D. |
| Contributor |
Severe obesity (BMI ≥35) is increasing at a 2 to 3 times greater rate than Class I obesity (BMI 30-34). Successful intervention for the severely obese is primarily limited to bariatric surgery, with over 200,000 procedures performed yearly in the U.S. Despite an increasing use of bariatric surgery, long-term outcome studies following this intervention are very limited, and identification of clinical predictors of bariatric surgery durability is lacking. To address these important knowledge gaps, the proposed study will draw upon data obtained from long-term prospective gastric bypass study (n=1156) and from a gastric bypass patient registry (n=13,500; 1979-2012). These studies will explore 3 specific clinical questions in patients who have had the most popular bariatric surgical procedure, the Roux-en-Y gastric bypass (RYGB). • Does cardiorespiratory fitness (CRF) predict 2- and 6-year weight loss following RYGB? • Does RYGB influence the birth weight of babies born to women post-RYGB surgery? • Does the age at which RYGB surgery is performed influence longer term mortality outcomes? The following aims will be pursued. Aim 1 will test the association baseline and 2-year CRF with weight loss at 2- and 6-years, respectively. In addition, how well change in CRF from 2- to 6-years predicts weight regain 2- to 6-years will be tested. For analyses, data collected as part of a 6-year prospective study (n=1156) exploring long-term morbidity following RYGB surgery will be used. Aim 2 will test the association between RYGB surgery and the birth weight of babies born to mothers before and following their RYGB surgery. Data from a large RYGB registry (n=13,500) and from matched nonbariatric surgery control mothers and their babies will be used to identify birth weights using birth certificates from the Utah Population Database. Aim 3 will test the association between the age of patients when undergoing RYGB surgery and subsequent long-term mortality. Mortality data obtained from the National Death Index bureau on post-RYGB surgical patients (n=7925) and matched, nonoperated, severely obese Utah drivers license applicants (n=7925), will be used for data analyses. Results for these investigations promise to contribute to the clinical understanding of the long-term health effects following RYGB surgery. |
| Title |
Long-term clinical implications of gastric bypass surgery specific to cardiorespiratory fitness, pregnancy-related birth weight and age-related mortality |
| Date |
2014-08 |
| Type |
Text |
| Publisher |
University of Utah |
| Subject MESH |
Obesity; Body Mass Index; Comorbidity ; Gastric Bypass; Bariatric Surgery; Weight Loss; Cardiorespiratory Fitness; Pregnancy Complications; Maternal Age; Birth Weight; Outcome Assessment (Health Care) |
| Dissertation Institution |
University of Utah |
| Dissertation Name |
Doctor of Philosophy |
| Language |
eng |
| Relation is Version of |
Digital version of Long-Term Clinical Implications of Gastric Bypass Surgery Specific to Cardiorespiratory Fitness, Pregnancy-Related Birth Weight and Age-Related Mortality |
| Rights Management |
Copyright © Ted D. Adams 2014 |
| Format Medium |
application/pdf |
| Format Extent |
1,052,730 bytes |
| Source |
Original in Marriott Library Special Collections |
| ARK |
ark:/87278/s6p602ff |
| Setname |
ir_etd |
| ID |
1409366 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6p602ff |
