Automated Evaluation of Choroidal Thickness and Minimum Rim Width Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy

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Title Automated Evaluation of Choroidal Thickness and Minimum Rim Width Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy
Creator Ane Pérez-Sarriegui; Francisco Muñoz-Negrete; Susana Noval; Victoria De Juan; Gema Rebolleda
Affiliation Department of Ophthalmology (AP-S, FJM-N, VDJ, GR), Hospital Universitario Ramón y Cajal, Madrid, Spain; IRYCIS (FJM-N, GR), Hospital Universitario Ramón y Cajal, Madrid, Spain; Department of Ophthalmology (SN), Hospital Universitario La Paz, Madrid, Spain; and IdiPAZ (SN), Hospital Universitario La Paz, Madrid, Spain.
Subject Nonarteritic Anterior Ischemic Optic Neuropathy, NAION; Choroidal Thickness
Abstract The aim of this study was to evaluate and compare peripapillary choroidal thickness (pCT) and macular choroidal thickness (CT), Bruch membrane opening-minimum rim width (BMO-MRW), retinal nerve fiber layer (RNFL) thickness, and optic disc area among nonarteritic anterior ischemic optic neuropathy (NAION) eyes, the contralateral unaffected eyes, and healthy control eyes.; Twenty-six patients diagnosed with NAION (29 affected and 21 unaffected eyes) and 29 healthy matched control individuals (29 eyes) were analyzed by swept-source optical coherence tomography. All participants underwent scanning by Spectralis optical coherence tomography to analyze BMO-MRW, RNFL thickness, and optic disc area.; Mean pCT in the NAION eyes, unaffected fellow eyes, and the control group was 130.5 ± 72.1 μm, 149.6 ± 75.7 μm, and 103.7 ± 36.7 μm, respectively (analysis of variance [ANOVA], P = 0.04). Mean macular CT in the NAION eyes, unaffected fellow eyes, and the control group was 226.1 ± 79.8 μm, 244.6 ± 81.4 μm, and 189.9 ± 56.4 μm, respectively (ANOVA, P = 0.03). Mean and all sectorial RNFL and BMO-MRW thickness values were significantly thinner in the NAION eyes vs the unaffected fellow and control eyes (P ≤ 0.00). The unaffected fellow eyes in NAION patients showed a significantly thicker average and sectorial BMO-MRW values than control eyes (P ≤ 0.02) except for the nasal sector (P = 0.09). Mean optic disc area derived from BMO analysis was not significantly different among groups (ANOVA, P = 0.86).; The fellow unaffected eyes in patients with NAION showed significantly thicker mean peripapillary and macular choroidal and BMO-MRW thicknesses than disease-free control eyes. No differences in the mean optic disc area were found. Both a thick peripapillary choroid and a thick neuroretinal rim might contribute to the development of NAION or possibly be a secondary phenomenon.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2018-03
Type Text
Source Journal of Neuro-Ophthalmology, December 2018, Volume 38, Issue 1
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s6x96qg7
Setname ehsl_novel_jno
Date Created 2019-03-11
Date Modified 2019-03-11
ID 1404046
Reference URL https://collections.lib.utah.edu/ark:/87278/s6x96qg7
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