Epstein-Barr Virus Neuroretinitis in a Lung Transplant Patient

Update item information
Title Epstein-Barr Virus Neuroretinitis in a Lung Transplant Patient
Creator Yen C. Hsia, MD, Peter V. Chin-Hong, MD, Marc H. Levin, MD, PhD
Affiliation Departments of Ophthalmology (YCH, MHL) and Medicine (PVC-H), University of California San Francisco School of Medicine, San Francisco, California
Subject DNA, Viral; Eye Infections, Viral; Female; Herpesvirus 4, Human; Humans; Infectious Mononucleosis; Lung Transplantation; Magnetic Resonance Imaging; Middle Aged; Polymerase Chain Reaction; Positron Emission Tomography Computed Tomography Retinitis; Tomography, Optical Coherence; Visual Acuity; Visual Fields
Abstract Paraneoplastic optic neuropathy (PON) is a rare cause of vision loss usually associated with small cell lung cancer. Patients with this condition usually test positive for anti-collapsin response mediating protein-5 (CRMP-5). We describe a case of a 57-year-old woman with bilateral vision loss with the characteristic features of CRMP-5 PON including bilateral optic disc edema and vitreous cells. However, she was negative for anti-CRMP-5 including a negative Western blot on two occasions, but positive for Purkinje Cell Antibody (PCA)-2. Although paraneoplastic antibodies are more predictive of an underlying cancer than a specific syndrome, previously PON has not been associated with PCA-2. Based on this observation, we recommend that the workup should include PCA-2 antibodies in patients who present with bilateral optic neuropathy and vitreous cells.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2017-03
Type Text
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s66b18h7
Setname ehsl_novel_jno
Date Created 2018-07-25
Date Modified 2020-03-13
ID 1353377
Reference URL https://collections.lib.utah.edu/ark:/87278/s66b18h7
Back to Search Results