Detection of Thyroid Abnormalities in Aquaporin-4 Antibody-Seropositive Optic Neuritis Patients

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Title Detection of Thyroid Abnormalities in Aquaporin-4 Antibody-Seropositive Optic Neuritis Patients
Creator Shuo Zhao, MD, Huanfen Zhou, MD, Xudong Peng, MD, Shaoying Tan, PhD, MD, Zihao Liu, MD, Tingjun Chen, PhD, MD, Quangang Xu, PhD, MD, Shihui Wei, MD
Affiliation Department of Ophthalmology (SZ), Beijing Hospital, Beijing, China; Department of Ophthalmology (HZ), The First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing, China; Department of Ophthalmology (ST, TC, QX, SW), The Chinese People's Liberation Army General Hospital, Beijing, China; Department of Health Care (XP), The Chinese People's Liberation Army General Staff Department Guard Bureau, Beijing, China; and Department of Ophthalmology (ZL), The Chinese Dongzhimen Hospital, Beijing, China
Subject Adult; Aquaporin 4; Autoantibodies; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Optic Neuritis; Optic Neuritis; Optic Neuritis; Retrospective Studies; Thyroid Diseases
Abstract Although still rarely diagnosed, amyloid light chain (AL) amyloidosis is the most common form of systemic amyloidosis. It is characterized by misfolded monoclonal immunoglobulin light chain fragments that accumulate extracellularly as amyloid fibrils, with consequent organ dysfunction. We report 2 such cases where initial symptoms and signs were identical to and mistaken for those of giant cell arteritis, associated with polymyalgia rheumatica. Neither patient responded to high-dose corticosteroids; instead, their temporal artery biopsies revealed amyloid deposits and other investigations confirmed a diagnosis of systemic AL amyloidosis. Review of the literature reveals similar cases of diagnostic confusion spanning 75 years. We have summarized the findings and learning points from cases reported in the past 30 years and highlight the need for increased awareness and investigation of this underrecognized syndrome.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2017-03
Type Text
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s6q85k0q
Setname ehsl_novel_jno
Date Created 2018-07-25
Date Modified 2020-03-12
ID 1353373
Reference URL https://collections.lib.utah.edu/ark:/87278/s6q85k0q
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