Characterizing Structural Optic Nerve Head Changes in High ICP and Strategies to Address Image Uncertainty

Candidate OCT based markers of high intracranial pressure(ICP) include optic nerve head volume(ONHV) and Bruch's membrane(BM) displacement into the eye. Both require identifying BM margins, but uncertainty is caused when swollen ONH reduce central BM image quality. The objectives of this study were to (1)determine the quantitative relationship between ONHV and Bruch's membrane displacement volume(BMDV) with ICP and (2)compare three strategies of addressing segmentation uncertainty.