Optical Coherence Tomography Angiography Findings in Pre-Clinical, Biomarker Positive Alzheimer's Disease

Alzheimer's disease (AD) is marked by slowly progressive memory loss, behavioral changes, and deterioration of executive function. Approved treatments prevent further neurodegeneration, but symptoms of AD only become apparent after irreversible loss has already occurred. Optical coherence tomography (OCT) and OCT angiography (OCTA) are noninvasive imaging techniques that allow analysis of retinal and microvascular anatomy. Here, we use OCT and OCTA technology to compare retinal architecture and vascularization between individuals with pre-clinical, biomarker positive AD and biomarker-negative age-matched controls.