Fundus Autofluorescence

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Identifier EEC_AF_NOVEL
Title Fundus Autofluorescence
Subject Ocular and Neurologic Evaluation, Fundus autofluorescence
Creator Jonathan A. Micieli, MD, Department of Ophthalmology, Emory University School of Medicine; Valérie Biousse, MD, Departments of Ophthalmology and Neurology, Emory University School of Medicine
Description The retinal pigment epithelium (RPE) has many important functions including phagocytosis of the photoreceptor outer segments. The metabolism of the photoreceptor outer segments leads to the formation of lipofuscin. Disease states and potentially increased oxidative damage can lead to the buildup of lipofuscin in the RPE (Figure 1). When stimulated with a broad wavelength of light, lipofuscin autofluoresces (Figure 2). Excess accumulation of lipofuscin leads to hyperautofluorescence whereas death of absence of the RPE leads to the disappearance of lipofuscin and hypoautofluorescence (Figure 3). The primary methods of obtaining fundus autofluorescence images include confocal scanning laser ophthalmoscopy and modified fundus photography. A normal fundus autofluorescence image is shown in Figures 4 and 5 and case examples of bilateral central scotomas from a macular dystrophy (Figures 6 and 7), acute macular neuroretinopathy (Figures 8 and 9), bull's-eye maculopathy from chloroquine toxicity (Figures 10 and 11), and pseudopapilledema from optic disc drusen (Figures 12 and 13) are shown.
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2018-03
Format application/pdf
Rights Management Copyright 2018. For further information regarding the rights to this collection, please visit:
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL
ARK ark:/87278/s6q85czs
Setname ehsl_novel_eec
Date Created 2018-03-21
Date Modified 2018-07-30
ID 1307532
Reference URL
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