Intralesional Injection of Bevacizumab for the Treatmentof an Apical Orbital Cavernous Venous Malformation

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Title Intralesional Injection of Bevacizumab for the Treatmentof an Apical Orbital Cavernous Venous Malformation
Creator Adam R. Sweeney, MD, Michael Chappell, MD, Derek A. Khorsand, MD, Arash Jian-Amadi, MD, Courtney E. Francis, MD
Affiliation Department of Ophthalmology (ARS, MC, AJA, CEF) and Department of Radiology (DAK), University of Washington, Seattle, Washington
Abstract Surgical excision of orbital cavernous venous malformations located in the orbital apex is challenging due to difficulty obtaining surgical exposure and higher risk of morbidity. Intralesional bevacizumab injection has been utilized for the treatment of choroidal and intracranial cavernous venous malformations. A 52-year-old woman with an orbital apical mass consistent with a cavernous venous malformation causing decreased visual acuity, diminished color vision, and visual field loss was treated with intralesional bevacizumab injected under direct surgical visualization. Subsequently, she demonstrated improved visual acuity, color vision, and slow but dramatic visual field improvement over one year. Injection of bevacizumab may be a viable alternative treatment for orbital cavernous venous malformations.
Subject Angiogenesis Inhibitors; Bevacizumab; Cavernous Sinus; Female; Humans; Injections, Intralesional; Intracranial Arteriovenous Malformations; Magnetic Resonance Imaging
OCR Text Show
Date 2016-12
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, December 2016, Volume 36, Issue 4
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s61g4jq6
Setname ehsl_novel_jno
ID 1293150
Reference URL https://collections.lib.utah.edu/ark:/87278/s61g4jq6
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