Longitudinal Study of Retinal Nerve Fiber Layer Thickness and Macular Volume in Patients With Neuromyelitis Optica; Spectrum Disorder

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Title Longitudinal Study of Retinal Nerve Fiber Layer Thickness and Macular Volume in Patients With Neuromyelitis Optica; Spectrum Disorder
Creator Praveena Manogaran, MSc, BSc, Anthony L. Traboulsee, MD, Alex P. Lange, MD
Affiliation Department of Medicine (PM, ALT), University of British Columbia, Vancouver, Canada; Department of Ophthalmology (APL), University of British Columbia, Vancouver, Canada; and Vista Klinik (APL), Binningen, Switzerland
Abstract Neuromyelitis spectrum disorder (NMOSD) is a rare autoimmune disorder previously thought to be a subtype of multiple sclerosis (MS). NMOSD is characterized by episodes of inflammation and damage to astrocytes that primarily results in damage to optic nerve and spinal cord. The objective of this exploratory study was to use optical coherence tomography (OCT) to measure axonal and neuronal health in NMOSD eyes over time.; Nine patients with definite NMOSD were assessed at baseline and follow-up visits (time between visits: 35-55 months). OCT assessment involved a macular volume protocol and a retinal nerve fiber layer (RNFL) thickness scan.; The temporal, inferior, nasal, or superior quadrant and the mean global RNFL thickness, macular thickness, and volume of each NMOSD patient was unchanged compared with baseline for each eye separately and both together. There also was no change between the 2 time points for the OCT measures for eyes affected and unaffected by optic neuritis and all eyes together except for a significant change in the temporal RNFL quadrant when all NMOSD eyes were pooled together (mean = 2.88 μm, SD = 3.7, P = 0.021).; Unlike in MS eyes, ongoing RNFL and macular thinning secondary to brain and optic nerve atrophy could not be observed in NMOSD eyes during an observation period of 4 years. This might be an additional marker to distinguish these 2 diseases. However, to confirm this finding, more long-term data are needed to compare these 2 diseases longitudinally.
Subject Adult; Female; Follow-Up Studies; Humans; Macula Lutea; Male; Middle Older people; Nerve Fibers; Neuromyelitis Optica; Optic Nerve; Retinal Ganglion Cells; Retrospective Studies; Time Factors; Tomography, Optical Coherence; Young Adult
OCR Text Show
Date 2016-12
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, December 2016, Volume 36, Issue 4
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6jd8v91
Setname ehsl_novel_jno
ID 1293146
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jd8v91
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