Introduction and Lessons from Vigabatrin (video)

Update item information
Identifier 20170406_nanos_nosideeffects1_01-video
Title Introduction and Lessons from Vigabatrin (video)
Creator Rod Foroozan, M.D., Baylor College of Medicine
Subject Vigabatrin, Visual field defect, Refractory complex partial seizures, Infantile spasms, Retinopathy
Description Vigabatrin was introduced as an anti-seizure medication in the United Kingdom in 1989 and was extensively used until 1997 when concerns for peripheral visual field defects emerged. When the drug was approved in the United States in 2009 it carried a black box warning for the risk of permanent visual loss and the pharmaceutical company was mandated to create a drug registry to assess for visual deficits. The vigabatrin drug registry has documented a relatively large percentage (37%) of pre-existing, baseline visual deficits involving the visual system and a paucity (2%) of potential new visual findings. The vigabatrin vision study, a prospective, longitudinal, single-arm, open-label study, confirmed that adult patients with refractory complex partial seizures had a large number (around 33%) of visual deficits at baseline, and a single patient who developed bilateral peripheral field constriction about one year after therapy. An unexpected finding during this first year of therapy with vigabatrin was an increase in retinal thickness on optical coherence tomography. The experience from; vigabatrin in the United States emphasizes the importance of baseline eye findings when considering the potential for drug toxicity involving the visual pathways.
Relation is Part of NANOS Annual Meeting 2017: Neuro-Ophthalmologic Side Effects of More Recently Used Medications in Treating Cancer, Rheumatologic Disorders, and Multiple Sclerosis
Contributor Primary Rod Foroozan, MD
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2017-04-05
Format video/mp4
Source 2017 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2013. For further information regarding the rights to this collection, please visit:
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL
Language eng
ARK ark:/87278/s62g1h10
Setname ehsl_novel_nam
Date Created 2017-10-03
Date Modified 2021-05-06
ID 1277284
Reference URL
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