Pediatric Optic Neuritis Prospective Outcomes Study

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Title Pediatric Optic Neuritis Prospective Outcomes Study
Creator Stacy L. Pineles, MD, Grant T. Liu, MD, Amy T. Waldman, MD,Elizabeth Lazar, MS, MPH, Mark J. Kupersmith, MD,Michael X. Repka, MD, MBA, for the Pediatric Eye Disease Investigator Groupand the Neuro-Ophthalmology Research Disease Investigator Consortium
Affiliation Jaeb Center for Health Research, Tampa, Florida; Pediatric Eye Disease Investigator Group and the Neuro-Ophthalmology Research Disease Investigator Consortium
Abstract To determine whether the size of the bony optic canal is associated with the severity of papilledema and poor visual function in idiopathic intracranial hypertension (IIH).; ; We performed a retrospective review of definite patients with IIH with requisite brain magnetic resonance imaging allowing for optic canal measurement. Clinical characteristics and automated (Humphrey) visual field results were reviewed; papilledema was graded according to the modified Frisén scale. Cross-sectional area of the optic canals was measured independently by 2 readers and averaged for each canal. Logistic regression modeling was applied.; ; Sixty-nine patients with IIH were included (mean age: 33; 91% women; 65% black). Controlling for age, sex, body mass index, race, and cerebrospinal fluid (CSF) opening pressure, each mm increase in canal size was associated with a 0.50 dB reduction in Humphrey visual field mean deviation (P = 0.006); this was likely mediated by the increased odds of Grade 4-5 papilledema or optic atrophy in patients with larger canals (odds ratio: 1.30 [95% CI: 1.10-1.55; P = 0.003] for Grade 4-5 papilledema or atrophy vs grade <4 papilledema per mm increase in canal size).; ; Poor visual function and severe papilledema or optic atrophy were associated with a larger optic canal. Potential mechanisms include alteration of local CSF flow or bony remodeling at the optic canals.
Subject Adult; Brain; Cerebrospinal Fluid Pressure; Female; Humans; Magnetic Resonance Imaging; Male; Optic Nerve; Papilledema; Pseudotumor Cerebri; Retrospective Studies; Severity of Illness Index; Visual Acuity; Visual Fields
OCR Text Show
Date 2016-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, June 2016, Volume 36, Issue 2
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s62v69kc
Setname ehsl_novel_jno
ID 1276483
Reference URL https://collections.lib.utah.edu/ark:/87278/s62v69kc
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