Medullary Structures Relevant to Upbeat Nystagmus

Update item information
Identifier Medulla_Caudal_Upbeat_intercalatus_and_Roller
Title Medullary Structures Relevant to Upbeat Nystagmus
Subject Medulla OMS; Figures
Creator Daniel R. Gold, DO, Departments of Neurology, Ophthalmology, Neurosurgery, Otolaryngology - Head & Neck Surgery, Emergency Medicine, and Medicine, The Johns Hopkins School of Medicine
Description This is an axial section of the medulla, slightly more caudal as compared to (please refer to figure "medullary structures relevant to the ocular motor and vestibular consequences of the lateral medullary (Wallenberg) syndrome). Again seen are the inferior cerebellar peduncle (ICP) and caudal aspect of the vestibular nucleus (medial vestibular nucleus [MVN]), in addition to the nucleus of Roller and nucleus intercalatus. These nuclei normally have an inhibitory influence over the flocculus, and when there is a lesion of Roller/intercalatus, there is less inhibition of the flocculus. The Purkinje cells of the flocculus normally inhibit the anti-gravity/anterior semicircular canal (SCC) pathways. With a lesion of Roller/intercalatus, the flocculus will over-inhibit the anterior SCC pathways, causing relative activation of the posterior SCC pathways which will generate a downward slow phase. The fast/position-reset phase will be upward, and these alternating slow (downward) and fast (upward) phases are responsible for upbeat nystagmus.
Contributor Daniel R. Gold, D.O.
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2017
Type Image
Format image/jpeg
Relation is Part of NOVEL: Neuro-ophthalmology Virtual Education Library Examination Collection
Rights Management Copyright 2017. For further information regarding the rights to this collection, please visit:
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E, SLC, UT 84112-5890
Collection Neuro-ophthalmology Virtual Education Library: NOVEL
Language eng
ARK ark:/87278/s61v97xv
Setname ehsl_novel_gold
Date Created 2017-08-10
Date Modified 2021-05-06
ID 1260005
Reference URL
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