Miller Fisher Syndrome - Ophthalmoplegia and Hyperreflexia

Update item information
Identifier MFS_with_HYPER_DTR-Gold
Title Miller Fisher Syndrome - Ophthalmoplegia and Hyperreflexia
Subject Range of eye movements/motility abnormal; Horizontal gaze palsy; Miller Fisher Syndrome
Creator Daniel R. Gold, DO, Departments of Neurology, Ophthalmology, Neurosurgery, Otolaryngology - Head & Neck Surgery, Emergency Medicine, and Medicine, The Johns Hopkins School of Medicine
Description This is a 45-yo-woman who presented with mild imbalance and diplopia. There had been a preceding viral illness several weeks prior. Examination demonstrated horizontal gaze paresis (sparing unilateral adduction), mild gait ataxia (no clear appendicular ataxia), and hyperreflexia. Pupils were sluggish OU. Her anti-Gq1b antibodies came back very high and MFS was diagnosed. IVIG was given, and there was gradual improvement (of all symptoms/signs) back to her baseline over 3-6 months. While the typical triad includes ophthalmoplegia, ataxia, and HYPOreflexia, occasionally, HYPERreflexia is seen instead as in our patient. There may also be overlap between MFS and Bickerstaff's brainstem encephalitis - however, our patient had no symptoms or signs (aside from potentially her hyperreflexia) referable to the brainstem. Brain MRI was normal.
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2016
Type Image/MovingImage
Format video/mp4
Rights Management Copyright 2016. For further information regarding the rights to this collection, please visit:
Collection Neuro-ophthalmology Virtual Education Library: NOVEL
File Name MFS_with_HYPER_DTR-Gold.mp4
Language eng
ARK ark:/87278/s62v64d2
Setname ehsl_novel_gold
Date Created 2017-02-28
Date Modified 2017-08-09
ID 1209840
Reference URL
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