| Identifier |
20190319_nanos_posters_164 |
| Title |
Development of a Novel Gene Therapy Using SIRT1 Signaling for Neuro-protection in Optic Neuropathies |
| Creator |
Ahmara G. Ross; Devin McDougald; Reas Khan; Kimberly Dine; Jean Bennett; Kenneth Shindler |
| Affiliation |
(AGR) University of Pennsylvania, Philadelphia, Pennsylvania; (DM) (JB) Center for Advanced Retinal and Ocular Therapeutics/ UPenn, Philadelphia, Pennsylvania; (RK) (KD) (KS) F. M. Kirby Center for Molecular Ophthalmology/ UPenn, Philadelphia, Pennsylvania |
| Subject |
Optic Neuropathy; Optic Nerve Trauma and Treatment; Miscellaneous |
| Description |
Pharmacologic activators and genetic overexperession of sirtuin 1 (SIRT1) promote neuroprotective effects in multiple neurodegenerative disease models, including optic neuropathies. AAV2-SIRT1 mediated overexpression in mouse retina partially attenuates experimental optic neuritis despite only a 21% transduction efficiency for retinal ganglion cells (RGCs) using the AAV2-GFP vector for quantification. Viral vectors with increased transduction efficiency are needed. |
| Date |
2019-03 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2019 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NAM 2019: Poster Session II: Scientific Advancements in Neuro-Ophthalmology |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6bk5x0j |
| Setname |
ehsl_novel_nam |
| ID |
1432646 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6bk5x0j |
