Human Adjuvant Disease (HAD) by Silicone Breast Implant (Siliconosis). A Emerging Condition?

Silicone breast prosthesis has been associated with a variety of medical conditions or autoimmune diseases, which has coincidental relation with the implants insertion; it's loomed as a new and unknown pathology of the modern times. More than 87 % of symptomatic patients developed demyelination axonal neuropathy demonstrated by nerve and muscle biopsy; 22 % to 25 % have evidence of autoimmune thyroid disease. An a small group of patients (10.%-12.%) have primary central nervous system demyelination disease as, multiple sclerosis. The diagnosis of multiple sclerosis was corroborated by magnetic resonance imaging and cerebrospinal fluid analysis. Also, an other wide spectrum of immunological diseases have been observed, such as fibromyalgia, Hashimoto's thyroiditis, polymyositis, dermatomyositis, lupus erythematosus, rheumatoid arthritis, scleroderma, and the presence of autoantibodies. Finally, for symptomatic patients, an adjuvant syndrome of silicone breast prosthesis or implant is proposed as a unitary diagnosis. The authors presented four patients whom illustrated this entity.