| Publication Type |
journal article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M. |
| Other Author |
Platt, Randall J.; Han, Tiffany S.; Green, Brad R.; Smith, Misty D.; Skalicky, Jack; Gruszczyński, Pawel; White, H. Steve; Bulaj, Grzegorz; Gajewiak, Joanna |
| Title |
Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors |
| Date |
2012-01-01 |
| Description |
Background: Can dicarba bridges (stapling) replace noncovalent interactions that stabilize helical conformation of neuroactivepeptides? Results: A rational design, synthesis, structural, and functional characterization of stapled conG analogs that target NMDAreceptors is reported. Conclusion: Stapled conG analogs are potent antagonists of NMDA receptors and anticonvulsant compounds. Significance: Stapling can be successfully applied to convert neuroactive peptides into drug leads. |
| Type |
Text |
| Publisher |
American Soc. for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
287 |
| Issue |
24 |
| First Page |
20727 |
| Last Page |
20736 |
| Dissertation Institution |
University of Utah |
| Language |
eng |
| Bibliographic Citation |
Platt, R. J., Han, T. S., Green, B. R., Smith, M. D., Skalicky, J., Gruszczyński, P., White, H. S., Olivera, B., Bulaj, G., & Gajewiak, J. (2012). Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. Journal of Biological Chemistry, 287(24), 20727-36. |
| Rights Management |
©American Society for Biochemistry and Molecular Biology |
| Format Medium |
application/pdf |
| Format Extent |
463,045 bytes |
| Identifier |
uspace,17534 |
| ARK |
ark:/87278/s6kh162q |
| Setname |
ir_uspace |
| ID |
708046 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6kh162q |
