| Identifier |
20240305_nanos_sciplatform3_06 |
| Title |
Vision-Related Quality of Life in LHON Patients Treated with Lenadogene Nolparvovec Gene Therapy: Analysis of the VFQ-25 Using Rasch Measurement Theory |
| Creator |
Benson Chen; John Britton; Magali Taiel; Patrick Yu-Wai-Man; Mike Horton |
| Affiliation |
(BC) (JB) Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom; Cambridge Clinical Vision Laboratory, NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom; Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom; (MT) GenSight Biologics, Paris, France; (PY) John van Geest Centre for Brain Repair and MRC Mitochondrial Biology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom; Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, United Kingdom; Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; Institute of Ophthalmology, University College London, London, United Kingdom; (MH) Psychometric Laboratory for Health Sciences, University of Leeds, Leeds, United Kingdom |
| Subject |
Genetic Disease; Optic Neuropathy |
| Description |
The impact of gene therapy on vision-related quality of life (VRQoL) in Leber hereditary optic neuropathy (LHON) was previously investigated in three pivotal Phase III clinical trials (RESCUE, REVERSE, REFLECT) using the National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). The purpose of this study was to use Rasch measurement theory to evaluate changes in VRQoL in participants of RESCUE, REVERSE, and REFLECT. |
| Date |
2024-03 |
| References |
None provided. |
| Language |
eng |
| Format |
video/mp4 |
| Type |
Image/MovingImage |
| Source |
2024 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2024: Scientific Platform: Session III |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2024. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6bavekj |
| Setname |
ehsl_novel_nam |
| ID |
2589959 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6bavekj |
