Publication Type |
thesis |
School or College |
School of Medicine |
Department |
Biochemistry |
Author |
Perkins, Eugene Hafen |
Title |
Effect of immunization on defense mechanisms against infectious disease in irradiated animals |
Date |
1958-08 |
Description |
It was observed that a cellular infiltration of phagocytic cells induced in the peritoneum of x-irradiated mice by injection of a 0.1% glycogen saline solution enhanced the resistance of these animals to a later challenge of infection with K. pneumoniae. A single intraperitoneal injection of heterologous leukocytes (rat or rabbit) administered on any given day in the first postirradiation week failed to significantly reduce mortality of non-challenged irradiated mice. However animals which received two intraperitoneal injections of homologous phagocytic leukocytes at critical postirradiation periods exhibited reduced mortalities. Investigation carried on in vitro demonstrated that phagocytic cells of actively immunized animals had a enhanced ability to destroy or inhibit multiplication of viable organisms independent of demonstrable agglutinating antibody. Similarly in vivo experiments demonstrated that phagocytic cells of actively immunized animals had enhanced phagocytic function in that injections of these cells enhanced the resistance of irradiated mice to subsequent challenge with the homologous organisms whereas cell obtained from norm mice afforded no protection. |
Type |
Text |
Publisher |
University of Utah |
Subject MESH |
Communicable Diseases; Defense Mechanisms |
Dissertation Institution |
University of Utah |
Dissertation Name |
PhD |
Language |
eng |
Relation is Version of |
Digital reproduction of "The effect of immunization on defense mechanisms against infectious disease in irradiated animals." Spencer S. Eccles Health Sciences Library. |
Rights Management |
© Eugene Hafen Perkins. |
Format Medium |
application/pdf |
Format Extent |
5,913,363 bytes |
Identifier |
undthes,3834 |
Source |
Original University of Utah Spencer S. Eccles Health Sciences Library (no longer available) |
Funding/Fellowship |
The research report herein was supported under contract AD 18(600)946 with th eU.S.A.F. School of Aviation Medicine, Randolph Field, Texas. |
Master File Extent |
5,913,405 bytes |
ARK |
ark:/87278/s6js9sbt |
Setname |
ir_etd |
ID |
191841 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6js9sbt |